Table 3.
Lung function and risk of all major CHD events, fatal and nonfatal MI events, and case fatality during 20 years of follow-up
| FVC (l) |
P for trend | ||||
|---|---|---|---|---|---|
| 1 (<3.97) | 2 (3.97–) | 3 (4.43–) | 4 (4.87–) | ||
| n | 1,095 | 1,106 | 1,116 | 1,117 | |
| Major CHD | |||||
| Rate/1,000 P-years | 11.9 (225) | 9.9 (189) | 7.9 (157) | 6.1 (123) | |
| Model 1 | 1.56 (1.24–1.97) | 1.39 (1.11–1.76) | 1.19 (0.94–1.51) | 1.00 | <0.0001 |
| Model 2 | 1.25 (0.98–1.59) | 1.26 (1.00–1.60) | 1.09 (0.86–1.39) | 1.00 | 0.007 |
| Model 3 | 1.14 (0.88–1.47) | 1.23 (0.96–1.37) | 1.14 (0.88–1.47) | 1.00 | 0.16 |
| Fatal CHD | |||||
| Rate/1,000 P-years | 5.4 (102) | 4.3 (82) | 3.0 (59) | 1.9 (39) | |
| Model 1 | 1.91 (1.30–2.81) | 1.70 (1.16–2.51) | 1.32 (0.88–1.98) | 1.00 | <0.0001 |
| Model 2 | 1.48 (1.00–2.21) | 1.50 (1.01–2.22) | 1.15 (0.76–1.74) | 1.00 | 0.002 |
| Model 3 | 1.41 (0.92–2.16) | 1.52 (1.00–2.32) | 1.28 (0.82–1.98) | 1.00 | 0.03 |
| Nonfatal MI | |||||
| Rate/1,000 P-years | 6.5 (123) | 5.6 (107) | 4.9 (98) | 4.2 (84) | |
| Age-adjusted RR | 1.39 (1.04–1.86) | 1.25 (0.93–1.66) | 1.14 (0.85–1.53) | 1.00 | 0.04 |
| Risk factor adjusted # | 1.12 (0.82–1.51) | 1.15 (0.86–1.53) | 1.07 (0.79–1.44) | 1.00 | 0.38 |
| Case fatality (%) | 49.1 | 41.1 | 36.7 | 28.7 | |
| Age-adjusted OR | 1.40 (0.86–2.27) | 1.40 (0.86–2.29) | 1.19 (0.72–1.98) | 1.00 | P = 0.03 |
| + CRP + preexisting CHD | 1.30 (0.80–2.14) | 1.36 (0.83–2.22) | 1.18 (0.71–1.96) | 1.00 | P = 0.07 |
| FEV1 (l) |
|||||
|---|---|---|---|---|---|
| 1 (<2.95) | 2 (2.95–) | 3 (3.41–) | 4 (3.81–) | ||
| n | 1,108 | 1,107 | 1,111 | 1,108 | |
| Major CHD | |||||
| Rate/1,000 P-years | 12.1 (228) | 10.0 (190) | 8.2 (161) | 5.6 (115) | |
| Model 1 | 1.66 (1.31–2.11) | 1.44 (1.14–1.83) | 1.32 (1.03–1.67) | 1.00 | <0.0001 |
| Model 2 | 1.28 (1.00–1.65) | 1.18 (0.93–1.51) | 1.17 (0.92–1.49) | 1.00 | 0.002 |
| Model 3 | 1.15 (0.88–1.50) | 1.12 (0.87–1.43) | 1.20 (0.93–1.55) | 1.00 | 0.12 |
| Fatal CHD | |||||
| Rate/1,000 P-years | 6.0 (112) | 4.1 (78) | 3.0 (59) | 1.6 (33) | |
| Model 1 | 2.41 (1.60–3.63) | 1.80 (1.19–2.73) | 1.57 (1.02–2.40) | 1.00 | <0.0001 |
| Model 2 | 1.81 (1.19–2.76) | 1.46 (0.96–2.23) | 1.37 (0.89–2.11) | 1.00 | 0.0003 |
| Model 3 | 1.63 (1.03–2.67) | 1.46 (0.93–2.29) | 1.42 (0.90–2.25) | 1.00 | 0.01 |
| Nonfatal MI | |||||
| Rate/1,000 P-years | 6.1 (116) | 5.9 (112) | 5.2 (102) | 4.0 (82) | |
| Age-adjusted RR | 1.32 (0.97–1.79) | 1.30 (0.97–1.73) | 1.22 (0.91–1.63) | 1.00 | 0.02 |
| Risk factor adjusted # | 1.02 (0.74–1.41) | 1.04 (0.77–1.40) | 1.09 (0.81–1.47) | 1.00 | 0.35 |
| Case fatality (%) | 45.3 | 43.4 | 37.6 | 31.7 | |
| Age-adjusted OR | 1.77 (1.06–2.95) | 1.36 (0.81–2.27) | 1.26 (0.74–2.13) | 1.00 | 0.03 |
| + CRP + preexisting CHD | 1.65 (0.97–2.79) | 1.31 (0.78–2.21) | 1.22 (0.72–2.07) | 1.00 | 0.06 |
Model 1, age adjusted; Model 2, Model 1 + adjusted for BMI, smoking, physical activity, alcohol intake, social class, preexisting evidence of CHD (undiagnosed), sBP, cholesterol, and HDL cholesterol; and Model 3, Model 2 + CRP + IL-6. OR, odds ratio.