Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1966 Oct;45(10):1569–1586. doi: 10.1172/JCI105463

The sources of bile pigment in the rat: studies of the "early labeled" fraction.

S H Robinson, M Tsong, B W Brown, R Schmid
PMCID: PMC292838  PMID: 5925515

Full text

PDF
1569

Images in this article

1578Image
on p.1578
1578Image
on p.1578
1579Image
on p.1579
1579Image
on p.1579

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERENDES M. The proportion of reticulocytes in the erythrocytes of the spleen as compared with those of circulating blood, with special reference to hemolytic states. Blood. 1959 May;14(5):558–563. [PubMed] [Google Scholar]
  2. BERENDSOHN S., LOWMAN J., SUNDBERG D., WATSON C. J. IDIOPATHIC DYSERYTHROPOIETIC JAUNDICE. Blood. 1964 Jul;24:1–18. [PubMed] [Google Scholar]
  3. BERLIN N. I., HEWITT C., LOTZ C. Hippuric acid synthesis in man after the administration of [alpha-14C]Glycine. Biochem J. 1954 Nov;58(3):498–503. doi: 10.1042/bj0580498. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BERLIN N. I., NEUBERGER A., SCOTT J. J. The metabolism of delta -aminolaevulic acid. 2. Normal pathways, studied with the aid of 14C. Biochem J. 1956 Sep;64(1):90–100. doi: 10.1042/bj0640090. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CROSBY W. H., MUNN J. I., FURTH F. W. Standardizing a method for clinical hemoglobinometry. U S Armed Forces Med J. 1954 May;5(5):693–703. [PubMed] [Google Scholar]
  6. DE MATTEIS F., RIMINGTON C. Disturbance of porphyrin metabolism caused by griseofulvin in mice. Br J Dermatol. 1963 Mar;75:91–104. doi: 10.1111/j.1365-2133.1963.tb13945.x. [DOI] [PubMed] [Google Scholar]
  7. FESSAS P. Inclusions of hemoglobin erythroblasts and erythrocytes of thalassemia. Blood. 1963 Jan;21:21–32. [PubMed] [Google Scholar]
  8. FLETCHER M. J., SANADI D. R. Turnover of rat-liver mitochondria. Biochim Biophys Acta. 1961 Aug 5;51:356–360. doi: 10.1016/0006-3002(61)90177-9. [DOI] [PubMed] [Google Scholar]
  9. GARFINKEL D., LAJTHA A. A metabolic inhomogeneity of glycine in vivo. I. Experimental determination. J Biol Chem. 1963 Jul;238:2429–2434. [PubMed] [Google Scholar]
  10. GIBLETT E. R., COLEMAN D. H., PIRZIOBIROLI G., DONOHUE D. M., MOTULSKY A. G., FINCH C. A. Erythrokinetics: quantitative measurements of red cell production and destruction in normal subjects and patients with anemia. Blood. 1956 Apr;11(4):291–309. [PubMed] [Google Scholar]
  11. GRAY C. H., KULCZYCKA A., NICHOLSON D. C., MAGNUS I. A., RIMINGTON C. ISOTOPE STUDIES ON A CASE OF ERYTHROPOIETIC PROTOPORPHYRIA. Clin Sci. 1964 Feb;26:7–15. [PubMed] [Google Scholar]
  12. GRAY C. H., NEUBERGER A., SNEATH P. H. A. Studies in congenital porphyria. 2. Incorporation of 15N in the stercobilin in the normal and in the porphyric. Biochem J. 1950 Jun-Jul;47(1):87–92. doi: 10.1042/bj0470087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. GRAY C. H., SCOTT J. J. The effect of haemorrhage on the incorporation of [alpha-14C]Glycine into stercobilin. Biochem J. 1959 Jan;71(1):38–42. doi: 10.1042/bj0710038. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. GRINSTEIN M., BANNERMAN R. M., VAVRA J. D., MOORE C. V. Hemoglobin metabolism in thalassemia. In vivo studies. Am J Med. 1960 Jul;29:18–32. doi: 10.1016/0002-9343(60)90004-8. [DOI] [PubMed] [Google Scholar]
  15. HUGHES JONES N. C., CHENEY B. The use of 51Cr and 59Fe as red cell labels to determine the fate of normal erythrocytes in the rat. Clin Sci. 1961 Jun;20:323–332. [PubMed] [Google Scholar]
  16. ISRAELS L. G., YAMAMOTO T., SKANDERBEG J., ZIPURSKY A. Shunt bilirubin: evidence for two components. Science. 1963 Mar 15;139(3559):1054–1055. doi: 10.1126/science.139.3559.1054. [DOI] [PubMed] [Google Scholar]
  17. JAMES G. W., 3rd, ABBOTT L. D., Jr Stercobilin N15 excretion in refractory anemia. Trans Am Clin Climatol Assoc. 1961;73:110–120. [PMC free article] [PubMed] [Google Scholar]
  18. JAMES G. W., 3rd Stercobilin and hematopoiesis. Am J Clin Nutr. 1955 Jan-Feb;3(1):64–71. doi: 10.1093/ajcn/3.1.64. [DOI] [PubMed] [Google Scholar]
  19. KEIGHLEY G., HAMMOND D., LOWY P. H. THE SUSTAINED ACTION OF ERYTHROPOIETIN INJECTED REPEATEDLY INTO RATS AND MICE. Blood. 1964 Jan;23:99–107. [PubMed] [Google Scholar]
  20. KLINGENBERG M. Pigments of rat liver microsomes. Arch Biochem Biophys. 1958 Jun;75(2):376–386. doi: 10.1016/0003-9861(58)90436-3. [DOI] [PubMed] [Google Scholar]
  21. LABBE R. F., HANAWA Y., LOTTSFELDT F. I. Heme and fatty acid biosynthesis in experimental porphyria. Arch Biochem Biophys. 1961 Feb;92:373–374. doi: 10.1016/0003-9861(61)90364-2. [DOI] [PubMed] [Google Scholar]
  22. LABBE R. F., NISHIDA G. A new method of hemin isolation. Biochim Biophys Acta. 1957 Nov;26(2):437–437. doi: 10.1016/0006-3002(57)90033-1. [DOI] [PubMed] [Google Scholar]
  23. LESTER R., SCHUMER W., SCHMID R. INTESTINAL ABSORPTION OF BILE PIGMENTS. IV. UROBILINOGEN ABSORPTION IN MAN. N Engl J Med. 1965 May 6;272:939–943. doi: 10.1056/NEJM196505062721803. [DOI] [PubMed] [Google Scholar]
  24. LITTLE J. R., BRECHER G., BRADLEY T. R., ROSE S. Determination of lymphocyte turnover by continuous infusion of H3 thymidine. Blood. 1962 Feb;19:236–242. [PubMed] [Google Scholar]
  25. LONDON I. M., WEST R., SHEMIN D., RITTENBERG D. On the origin of bile pigment in normal man. J Biol Chem. 1950 May;184(1):351–358. [PubMed] [Google Scholar]
  26. LONDON I. M., WEST R., SHEMIN D., RITTENBERG D. Porphyrin formation and hemoglobin metabolism in congenital porphyria. J Biol Chem. 1950 May;184(1):365–371. [PubMed] [Google Scholar]
  27. LONDON I. M., WEST R. The formation of bile pigment in pernicious anemia. J Biol Chem. 1950 May;184(1):359–364. [PubMed] [Google Scholar]
  28. Labbe R. F., Kurumada T., Onisawa J. The role of succinyl-CoA synthetase in the control of heme biosynthesis. Biochim Biophys Acta. 1965 Dec 16;111(2):403–415. doi: 10.1016/0304-4165(65)90050-4. [DOI] [PubMed] [Google Scholar]
  29. Marver H. S., Tschudy D. P., Perlroth M. G., Collins A. Delta-aminolevulinic acid synthetase. I. Studies in liver homogenates. J Biol Chem. 1966 Jun 25;241(12):2803–2809. [PubMed] [Google Scholar]
  30. NEUBERGER A. Aspects of the metabolism of glycine and of porphyrins. Biochem J. 1961 Jan;78:1–10. doi: 10.1042/bj0780001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. OLIVERIO V. T., DENHAM C., DAVIDSON J. D. Oxygen flask combustion in determination of C-14 and H3 in biological materials. Anal Biochem. 1962 Aug;4:188–189. doi: 10.1016/0003-2697(62)90035-0. [DOI] [PubMed] [Google Scholar]
  32. OSTROW J. D., HAMMAKER L., SCHMID R. The preparation of crystalline bilirubin-C14. J Clin Invest. 1961 Aug;40:1442–1452. doi: 10.1172/JCI104375. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. OSTROW J. D., JANDL J. H., SCHMID R. The formation of bilirubin from hemoglobin in vivo. J Clin Invest. 1962 Aug;41:1628–1637. doi: 10.1172/JCI104620. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. PRICE V. E., STERLING W. R., TARANTOLA V. A., HARTLEY R. W., Jr, RECHCIGL M., Jr The kinetics of catalase synthesis and destruction in vivo. J Biol Chem. 1962 Nov;237:3468–3475. [PubMed] [Google Scholar]
  35. RIMINGTON C., CRIPPS D. J. BIOCHEMICAL AND FLUORESCENCE-MICROSCOPY SCREENING-TESTS FOR ERYTHROPOIETIC PROTOPORPHYRIA. Lancet. 1965 Mar 20;1(7386):624–626. doi: 10.1016/s0140-6736(65)91714-9. [DOI] [PubMed] [Google Scholar]
  36. ROBINSON S. H., SCHMID R. THE RELATION OF ERYTHROPOIESIS TO BILE PIGMENT FORMATION. Medicine (Baltimore) 1964 Nov;43:667–668. doi: 10.1097/00005792-196411000-00009. [DOI] [PubMed] [Google Scholar]
  37. ROBINSON S., VANIER T., DESFORGES J. F., SCHMID R. Jaundice in thalassemia minor: a consequence of "ineffective erythropoiesis". N Engl J Med. 1962 Sep 13;267:523–529. doi: 10.1056/NEJM196209132671101. [DOI] [PubMed] [Google Scholar]
  38. Robinson S. H., Owen C. A., Jr, Flock E. V., Schmid R. Bilirubin formation in the liver from nonhemoglobin sources. Experiments with isolated, perfused rat liver. Blood. 1965 Dec;26(6):823–829. [PubMed] [Google Scholar]
  39. SCHIMKE R. T., SWEENEY E. W., BERLIN C. M. THE ROLES OF SYNTHESIS AND DEGRADATION IN THE CONTROL OF RAT LIVER TRYPTOPHAN PYRROLASE. J Biol Chem. 1965 Jan;240:322–331. [PubMed] [Google Scholar]
  40. SCHMID R., FIGEN J. F., SCHWARTZ S. Experimental porphyria. IV. Studies of liver catalase and other heme enzymes in sedormid porphyria. J Biol Chem. 1955 Nov;217(1):263–274. [PubMed] [Google Scholar]
  41. SCHMID R., HAMMAKER L. METABOLISM AND DISPOSITION OF C14-BILIRUBIN IN CONGENITAL NONHEMOLYTIC JAUNDICE. J Clin Invest. 1963 Nov;42:1720–1734. doi: 10.1172/JCI104858. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. SMITH I. D., SIMMONDS W. J. The changes in cardiac output, right atrial pressure and blood volume in haemorrhagic anaemias in unanaesthetized rabbits. Aust J Exp Biol Med Sci. 1954 Apr;32(2):241–252. doi: 10.1038/icb.1954.28. [DOI] [PubMed] [Google Scholar]
  43. SNYDER A. L., SCHMID R. THE CONVERSION OF HEMATIN TO BILE PIGMENT IN THE RAT. J Lab Clin Med. 1965 May;65:817–824. [PubMed] [Google Scholar]
  44. Schimke R. T., Sweeney E. W., Berlin C. M. Studies of the stability in vivo and in vitro of rat liver tryptophan pyrrolase. J Biol Chem. 1965 Dec;240(12):4609–4620. [PubMed] [Google Scholar]
  45. VAVRA J. D., MAYER V. K., MOORE C. V. IN VITRO HEME SYNTHESIS BY HUMAN BLOOD: ABNORMAL HEME SYNTHESIS IN THALASSEMIA MAJOR. J Lab Clin Med. 1964 May;63:736–753. [PubMed] [Google Scholar]
  46. WATSON C. J. Recent studies of the urobilin problem. J Clin Pathol. 1963 Jan;16:1–11. doi: 10.1136/jcp.16.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. WATTS R. W., CRAWHALL J. C. The first glycine metabolic pool in man. Biochem J. 1959 Oct;73:277–286. doi: 10.1042/bj0730277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. WEBER A. P., SCHALM L. Quantitative separation and determination of bilirubin and conjugated bilirubin in human serum. Clin Chim Acta. 1962 Nov;7:805–810. doi: 10.1016/0009-8981(62)90063-3. [DOI] [PubMed] [Google Scholar]
  49. WHYTE H. M. Plasma and blood volume in anaemia and the effect of transfusion. Australas Ann Med. 1956 Aug;5(3):192–202. doi: 10.1111/imj.1956.5.3.192. [DOI] [PubMed] [Google Scholar]
  50. Watson C. J. The continuing challenge of hemoglobin and bile pigment metabolism. Ann Intern Med. 1965 Dec;63(6):931–944. doi: 10.7326/0003-4819-63-6-931. [DOI] [PubMed] [Google Scholar]
  51. YAMAMOTO T., SKANDERBEG J., ZIPURSKY A., ISRAELS L. G. THE EARLY APPEARING BILIRUBIN: EVIDENCE FOR TWO COMPONENTS. J Clin Invest. 1965 Jan;44:31–41. doi: 10.1172/JCI105124. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES