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. Author manuscript; available in PMC: 2012 Aug 10.
Published in final edited form as: Behav Brain Res. 2010 Apr 2;221(2):610–622. doi: 10.1016/j.bbr.2010.03.036

Figure 2.

Figure 2

Spatial memory deficits were attenuated following memantine treatment in Ts65Dn mice. A, Activity was measured over a one-hour session (distance traveled, cm). Ts65Dn Control and Ts65Dn Mem mice show greater spontaneous activity than NS Control and Mem mice. Memantine treatment did not significantly affect either genotype (Genotype effect: **p<0.01). B, Performance in a win-stay RA maze task is indicated by errors per trial across days. NS Control mice show reduced errors across days. While Ts65Dn Control mice performed significantly more errors on days 2 and 3 than NS Controls, Ts65Dn Mem mice show a reduction in errors relative to Ts65Dn Controls. Memantine treatment had no effect on NS mice (Days 2–3: *p<0.05 compared with NS mice, ^p<0.05 between Ts65Dn Mem and Ts65Dn control groups; mean ± SEM).