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. Author manuscript; available in PMC: 2012 Aug 10.
Published in final edited form as: Behav Brain Res. 2010 Apr 2;221(2):610–622. doi: 10.1016/j.bbr.2010.03.036

Figure 7.

Figure 7

Microglial activity was not reduced in the hippocampus of Ts65Dn mice following memantine treatment. A–C, CD45-positive microglia in the CA1 of the hippocampus exhibit lower immunoreactivity indicative of a “resting” state in NS Control mice (A). Ts65Dn control (B) and memantine-treated (C) mice show larger microglia with greater staining density, consistent with an increased microglial activity (scale bars = 100 µm, 20 µm for inset). D, Microglial immunoreactivity in the hippocampus is elevated in Ts65Dn mice, and is not affected by memantine-treatment (*p<0.05; Immunoreactivity normalized to background; mean ± SEM).