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Memantine increased BDNF gene expression in the hippocampus of Ts65Dn mice. A, Ts65Dn Mem mice exhibited higher BDNF mRNA levels in the hippocampus compared to normosomic controls (p<0.05), while NS Mem mice did not differ from NS control mice. B, Protein measurements in frontal cortex tissue showed a significant increase in BDNF levels in Ts65Dn Mem mice relative to NS controls. This increase in BDNF was not observed in NS Mem mice (*p<0.05; Mean ± SEM).
