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. 2010 Sep;12(5):552–561. doi: 10.2353/jmoldx.2010.100098

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© 2010 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

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Overall view of gene expression dysregulations within chromosomal aberrations. Shown are the percentages of samples with gains (top chart), losses (middle chart), and copy neutral-LOH or somatic UPDs (bottom chart) in every autosomal chromosome. Each ellipse refers to a U133A probe set representing a gene located in the region of aberration with z ≥ 3 (up-regulated), or z ≤ −3 (down-regulated) in at least 10% of the CRC samples. Note that chromosomal gains and losses are populated by numerous genes that are up-regulated and down-regulated, respectively.