Table 1.
Characteristics of the Breast Cancers in This Study
| Series characteristics | Consecutive series (n = 99) |
Independent consecutive series |
|
|---|---|---|---|
| ER status | Positive and negative | Positive alone | Positive alone |
| Number of samples | n = 59 | n = 40 | n = 40 |
| RT-PCR direct sequencing | Yes | Yes | |
| DNA-based direct sequencing | Yes | ||
| Cycleave PCR | Yes | Yes | |
| Age, year | |||
| Median | 55 | 56 | 56 |
| Range | 28–82 | 33–76 | 26–78 |
| Tumor size | |||
| pTis | 2 | 0 | 6 |
| pT1 (<2 cm) | 28 | 24 | 23 |
| pT2 (2–5 cm) | 21 | 9 | 8 |
| pT3/4 (>5 cm) | 8 | 7 | 3 |
| Nodal status | |||
| pN0 | 23 | 17 | 26 |
| pN1–3 | 35 | 23 | 14 |
| Estrogen receptor status | |||
| Positive | 34 | 40 | 40 |
| Negative | 25 | 0* | 0* |
| Progesterone receptor status | |||
| Positive | 26 | 29 | 30 |
| Negative | 33 | 11 | 10 |
| HER2 status | |||
| Positive | 40 | 34 | 3 |
| Negative | 19 | 6 | 37 |
| Histological grade | |||
| Low-grade | 9 | 10 | 12 |
| Intermediate | 27 | 21 | 19 |
| High-grade | 23 | 9 | 9 |
| Histology | |||
| DCIS | 2 | 0 | 6 |
| IDC | 55 | 35 | 30 |
| ILC | 0 | 4 | 0 |
| Special types | 2 | 1 | 4 |
| p53 status | |||
| Wild type | 31 | 26 | 0 |
| Mutated | 17 | 7 | 0 |
| N.A. | 11 | 7 | 40 |
| E-cadherin status | |||
| Wild type | 53 | 31 | 0 |
| Mutated | 1* | 1* | 0 |
| N.D. | 6 | 8 | 40 |
DCIS indicates duct carcinoma in situ; IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; N.A., not done.
*
CDH1 mutation was detected in an invasive lobular carcinoma and an invasive ductal carcinoma with lobular carcinoma features.