Table 3.

Cox regression model of the adjuvant chemotherapy with regard to disease-free and overall survivals after liver metastasectomy

	Multivariate analysis with regard to disease-free survival			Multivariate analysis with regard to overall survival
Factor	HR	95% CI	P	HR	95% CI	P
Adjuvant chemotherapy
FU/LV	1			1
FOLFOX/FOLFIRI	0.37	0.15–0.94	0.036	0.27	0.083–0.86	0.026
Age (years)
≤70	1			1
>70	1.3	0.46–3.6	0.64	2.4	0.60–9.3	0.22
Stage of primary CRC
II	1			1
III	2.5	0.90–7.0	0.081	3.0	0.76–12	0.12
Maximum CLM size (cm)
>3	1			1
≤3	0.68	0.25–1.9	0.45	0.75	0.19–3.0	0.69
No. CLMs
1	1			1
≥2	1.2	0.47–2.8	0.76	0.81	0.24–2.7	0.73
Time from surgery of primary CRC to metastases (months)
≤12	1			1
>12	0.66	0.29–1.5	0.34	1.0	0.34–3.0	0.99
CLM resection margin
R0 resection	1			1
R1 resection	5.6	1.2–20	0.019	1.0	0.11–9.7	0.99
CEA at metastasectomy (ng/ml)
≤50	1			1
>50	1.8	0.70–4.8	0.21	2.1	0.59–7.3	0.25