. Author manuscript; available in PMC: 2011 Aug 15.

Published in final edited form as: Clin Infect Dis. 2010 Aug 15;51(4):468–471. doi: 10.1086/654797

Table 1.

Clinical Characteristics, Laboratory Results, and Treatment of Ocular Syphilis among Human Immunodeficiency Virus–Infected Patients

Patient	Age, years	CD4⁺ cell count, cells/μL	HIV RNA copies/ mL^a	Serum RPR level	CSF VDRL test result	CSF WBC count, cells/μL	Ocular examination result	Visual acuity		Antibiotic regimen^d	Syphilis recurrence
Patient	Age, years	CD4⁺ cell count, cells/μL	HIV RNA copies/ mL^a	Serum RPR level	CSF VDRL test result	CSF WBC count, cells/μL	Ocular examination result	Before treatment^b	After treatment^c	Antibiotic regimen^d	Syphilis recurrence
1	31	217	25,740	1:256	1:2	141	Panuveitis	20/800	20/63	Intravenous penicillin for 2 weeks, intramuscular penicillin for 3 weeks	No

2	38	532	<400	1:128	NR	12	Anterior uveitis	…	…	Intravenous penicillin for 2 weeks, intramuscular penicillin for 1 week	No

3	54	539	<50	1:256	NR	2	Posterior uveitis, optic neuritis	20/80	20/25	Intravenous penicillin for 2 weeks	No

4^e	41	228	188,000	1:2048	1:2	20	Panuveitis, optic neuritis	20/400	20/20	Intravenous penicillin for 2 weeks	Yes

5	52	237	174,000	1:128	NR	1	Anterior uveitis, optic neuritis	20/25	20/20	Intravenous penicillin for 3 weeks	No

6	36	745	54,500	1:1024	1:1	12	Panuveitis, optic neuritis	CF	20/20	Intravenous penicillin for 2 weeks intramuscular penicillin for 1 week	No

7	36	472	<50	1:256	NR	4	Posterior uveitis	20/320	20/25	Intravenous penicillin for 2 weeks, intramuscular penicillin for 3 weeks	Yes

8	36	780	3380	1:256	1:4	11	Posterior uveitis			Intravenous penicillin for 2 weeks, intramuscular penicillin for 3 weeks	No

9^f	26	348	1850	1:128	…	…	Anterior uveitis	20/20		Intramuscular/intravenous penicillin for 10 days	Yes

10	46	599	<50	1:256	NR	5	Anterior uveitis	20/60	20/25	Intramuscular penicillin for 10 days	No

11	23	747	240,222	1:512	1:16	187	Anterior uveitis	CF	20/40	Intravenous penicillin for 2 weeks	No

12	45	305	<48	1:64	NR	3	Optic neuritis	20/20	16/15	Intravenous penicillin for 1 week, oral doxycycline for 28 days	No
13	55	142	<48	1:128	NR	1	Panuveitis, optic neuritis	20/200	20/32	Intravenous penicillin for 2 weeks, intramuscular penicillin for 1 week	No

NOTE. CSF, cerebrospinal fluid; NR, nonreactive; RPR, rapid plasma reagin; WBC, white blood cell.

All 5 patients receiving antiretroviral therapy had viral loads less than the limit of detection.

Visual acuity scores of the more severely affected eye; CF, able to count fingers only from ≤3 feet; original reports detailing visual acuity examination unavailable for 2 patients.

All posttreatment visual acuities tested within 3 months.

Intravenous penicillin dosage was 24 MU daily; intramuscular penicillin, 2.4 MU weekly; oral doxycycline, 200 mg twice daily; patients 9 and 10 were treated with 2.4 MU intramuscular procaine penicillin daily with probenecid 500 mg 4 times per day; patient 9 was switched to intravenous penicillin after the fourth day.

Patient described in the case report.

Declined lumbar puncture.