Table 2.
Effect of BDNF Val66Met genotype and Depression on neuropsychological test measures.
| Mean test score by genotype | Effect of BDNF genotype |
Effect of Depression |
||||
|---|---|---|---|---|---|---|
| Task n | Val/Val n=171 | Val/Met n=93 | F | p | F | p |
| Word recall -immediate | 19.52(4.53) | 18.88 (5.15) | 0.06 | 0.80 | 31.4 | <0.0001 |
| Word recall - delayed | 6.49(2.22) | 6.40(2.54) | 0.18 | 0.67 | 26.5 | <0.0001 |
| Word recall % retained169/90 | 82.93 (22.55) | 83.15(28.53) | 0.12 | 0.73 | 4.27 | 0.04 |
| Word recall intrusions | 0.60(1.05) | 0.70(1.18) | 0.34 | 0.56 | 0.04 | 0.851 |
| Word List Recognition | 19.37(1.27) | 19.22(1.63) | 0.20 | 0.66 | 11.3 | 0.0009 |
| Logical Memory Immediate 170/93 | 25.58(8.29) | 24.47(9.11) | 0.09 | 0.76 | 20.33 | <0.0001 |
| Logical Memory Delayed 170/92 | 21.61(9.21) | 20.37(10.24) | 0.11 | 0.74 | 18.24 | <0.0001 |
| Logical Memory % retained 170/92 | 80.17(21.30) | 78.21(21.78) | 0.04 | 0.84 | 7.07 | 0.0083 |
| Visual Retention Test 170/90 | 6.05(1.96) | 5.60 (2.13) | 2.82 | 0.94 | 18.81 | <0.0001 |
| Praxis Recall 171/92 | 8.29(2.53) | 8.09(2.63) | 0.01 | 0.92 | 12.71 | 0.0004 |
| Digit Span Forward 149/78 | 8.80(2.34) | 8.42(2.32) | 1.53 | 0.22 | 0.78 | 0.378 |
| Digit Span Backward 149/77 | 7.11(2.25) | 7.45(2.69) | 0.86 | 0.36 | 3.06 | 0.081 |
n= number of people who completed each task, listed as val/val homozygotes / met allele carriers. If no value is listed, then the entire sample of 171 val/val homozygous individuals and 93 met allele carriers had data for that task. Data presented as mean (standard deviation). Statistical results derived from models where task performance was the dependent variable and BDNF genotype an independent variable, also controlling for diagnosis of depression, age, and education. The effect of depression was controlled for age, education and BDNF.