Table 2.
Sociodemographic, Psychosocial, and Regimen Characteristics by Short-Term (12 Month) HAART Regimen Status for 1852 HAART Regimens Used in the Treatment of 738 HIV-Infected Patients at the UAB 1917 HIV/AIDS Clinic, 1995–2004a
| |
|
|
Discontinued regimens by reason |
||||
|---|---|---|---|---|---|---|---|
| Variable | Active (N = 826) | Discontinued (N = 1026) | GI toxicity (N = 233) | Non-GI toxicity (N = 225) | Virologic failure/nonadherence (N = 172) | Loss to follow-up (N = 95) | Other (N = 301) |
| Age (years) | |||||||
| <30 | 86 (10.4) | 134 (13.1) | 17 (7.3) | 32 (14.2) | 27 (15.7) | 14 (14.7) | 44 (14.6) |
| 30–39 | 307 (37.2) | 481 (46.9) | 116 (49.8) | 95 (42.2) | 78 (45.3) | 50 (52.6) | 142 (47.2) |
| 40–50 | 309 (37.4) | 289 (28.2) | 60 (25.8) | 76 (33.8) | 43 (25.0) | 25 (26.3) | 85 (28.2) |
| >50 | 124 (15.0) | 122 (11.9) | 40 (17.2) | 22 (9.8) | 24 (14.0) | 6 (6.3) | 30 (10.0) |
| Gender | |||||||
| Female | 194 (23.5) | 298 (29.0) | 76 (32.6) | 82 (36.4) | 43 (25.0) | 18 (18.9) | 79 (26.2) |
| Male | 632 (76.5) | 728 (71.0) | 157 (67.4) | 143 (63.6) | 129 (75.0) | 77 (81.1) | 222 (73.8) |
| Race | |||||||
| Black | 379 (45.9) | 534 (52.0) | 118 (50.6) | 110 (48.9) | 104 (60.5) | 50 (52.6) | 152 (50.5) |
| White | 447 (54.1) | 492 (48.0) | 115 (49.4) | 115 (51.1) | 68 (39.5) | 45 (47.4) | 149 (49.5) |
| Men who have sex with men (MSM) | |||||||
| No | 385 (46.6) | 547 (53.3) | 127 (54.5) | 124 (55.1) | 92 (53.5) | 51 (53.7) | 153 (50.8) |
| Yes | 441 (53.4) | 479 (46.7) | 106 (45.5) | 101 (44.9) | 80 (46.5) | 44 (46.3) | 148 (49.2) |
| History of IV drug use | |||||||
| No | 773 (93.6) | 913 (89.0) | 198 (85.0) | 206 (91.6) | 148 (86.0) | 81 (85.3) | 280 (93.0) |
| Yes | 53 (6.4) | 113 (11.0) | 35 (15.0) | 19 (8.4) | 24 (14.0) | 14 (14.7) | 21 (7.0) |
| Insuranceb | |||||||
| None | 166 (20.1) | 248 (24.2) | 60 (25.8) | 56 (24.9) | 26 (15.1) | 29 (30.5) | 77 (25.6) |
| Private | 497 (60.2) | 492 (48.0) | 99 (42.5) | 116 (51.6) | 90 (52.3) | 42 (44.2) | 145 (48.2) |
| Public | 162 (19.6) | 278 (27.1) | 74 (31.8) | 52 (23.1) | 54 (31.4) | 21 (22.1) | 77 (25.6) |
| Depression | |||||||
| No | 552 (66.8) | 721 (70.3) | 145 (62.2) | 159 (70.7) | 121 (70.3) | 71 (74.7) | 225 (74.8) |
| Yes | 274 (33.2) | 305 (29.7) | 88 (37.8) | 66 (29.3) | 51 (29.7) | 24 (25.3) | 76 (25.2) |
| Substance abuse | |||||||
| No | 695 (84.1) | 872 (85.0) | 193 (82.8) | 198 (88.0) | 145 (84.3) | 77 (81.1) | 259 (86.0) |
| Yes | 131 (15.9) | 154 (15.0) | 40 (17.2) | 27 (12.0) | 27 (15.7) | 18 (18.9) | 42 (14.0) |
| NNRTI | |||||||
| No | 453 (54.8) | 601 (58.6) | 150 (64.4) | 110 (48.9) | 108 (62.8) | 46 (48.4) | 187 (62.1) |
| Yes | 374 (45.2) | 425 (41.4) | 83 (35.6) | 115 (51.1) | 64 (37.2) | 49 (51.6) | 114 (37.9) |
| PI | |||||||
| No | 402 (48.7) | 442 (43.1) | 83 (35.6) | 108 (48.0) | 65 (37.8) | 49 (51.6) | 137 (45.5) |
| Yes | 424 (51.3) | 584 (56.9) | 150 (64.4) | 117 (52.0) | 107 (62.2) | 46 (48.4) | 164 (54.5) |
| HAART regimen number | |||||||
| 1 | 357 (43.2) | 381 (37.1) | 78 (33.5) | 96 (42.7) | 56 (32.6) | 40 (42.1) | 111 (36.9) |
| 2 | 222 (26.9) | 243 (23.7) | 51 (21.9) | 51 (22.7) | 39 (22.7) | 28 (29.5) | 74 (24.6) |
| 3 | 124 (15.0) | 150 (14.6) | 38 (16.3) | 25 (11.1) | 29 (16.9) | 13 (13.7) | 45 (15.0) |
| ≥4 | 123 (14.9) | 252 (24.6) | 66 (28.3) | 53 (23.6) | 48 (27.9) | 14 (14.7) | 71 (23.6) |
a
Data presented as N (column percent).
b
Insurance type unknown in 9 of the 1852 regimens.