Table 1.

Effect of distension and drug treatments on control and VD urethral OD

	Control (n =8)			VD (n =9)
	Proximal	Middle	Distal	Proximal	Middle	Distal
%OD8mmHG	43.4 ± 6.5	29.4 ± 3.4*	18.7 ± 2.7	51.0 ± 4.6	16.0 ± 1.9*	20.8 ± 4.5
%ODNOSi	−0.2 ± 0.4	−0.9 ± 0.7	1.6 ± 0.4	0.2 ± 1.6	−0.6 ± 0.7	1.5 ± 0.7
%ODPE	−5.9 ± 1.3†	−6.3 ± 1.0	−4.2 ± 2.0	−11.2 ± 1.5†	−3.6 ± 1.0	−5.5 ± 1.9
%ODEDTA	9.8 ± 1.9	4.7 ± 0.7‡	14.1 ± 3.8	6.2 ± 1.5	10.5 ± 2.1‡	11.0 ± 2.7

Values are means ± SE. Functional results [percent outer diamter (%OD) changes] for proximal, middle, and distal segments of control and vaginal distension (VD) urethral specimens. Effects are indicated for abrupt 8 mmHg of static pressure, nitric oxide synthase inhibitor (NOSi), phenylephrine (PE), and EDTA. Positive values (+) indicate an increase in OD value (i.e., relaxation), and negative values (−) indicate a decrease in OD value (i.e., contractions).

^*P < 0.05, significantly different change in OD in response to 8 mmHg of intraurethral pressure between control and VD middle urethral segments.

^†P < 0.05, significantly different change in OD in response to PE between control and VD proximal segments.

^‡P < 0.05, significantly different change in OD response to EDTA between control and VD middle segments.