Fig. 3.

Urinary ammonia excretion and urine pH in response to HCl-induced metabolic acidosis. A: urinary ammonia excretion. Acid loading increased urine ammonia excretion in both control (C) and intercalated cell (IC)-Rhcg-knockout (KO) mice. There was no significant difference in urinary ammonia excretion before acid loading, or on days 1 or 2 of acid loading between C and IC-Rhcg-KO mice. On day 3, total urine ammonia was significantly less in IC-Rhcg-KO mice than in C mice. B: urine pH in response to acid loading. After acid loading, IC-Rhcg-KO mice excreted significantly more acid urine than did in C mice on days 1 and 2. *P < 0.01 vs. C. **P < 0.05 vs. C.