Other effects of IC-Rhcg-KO. A: titratable acid excretion. There was no significant difference in titratable acid excretion between C and IC-Rhcg-KO mice, either under baseline conditions or in response to acid loading. B: net acid excretion. Net acid excretion did not differ significantly between C and IC-Rhcg-KO mice before acid loading or on days 1 or 2 of acid loading and was significantly less in IC-Rhcg-KO mice on day 3 of acid loading. C: dietary food intake. Food intake, and thus acid ingestion, did not differ significantly between C and IC-Rhcg-KO mice, either under baseline conditions or with acid loading. D: changes in body weight. Metabolic acidosis induces weight loss, but there were no significant differences in weight loss between C and IC-Rhcg-KO mice. E: urine volume. Urine volume did not differ significantly between C and IC-Rhcg-KO mice either before or during acid-loading; n = 8 at each time point in all graphs. P = not significant (NS).