Table 2.

Morphological parameters and opsin levels in retinae of adult and aged B6D2F1/J mice

	Adult mice (4-month-old)	Aged mice (2.5-year-old)	p value
ONL thickness, μm	29.4 ± 0.5 (n = 196; 3 mice)	25.1 ± 0.4 (n = 196; 3 mice)	<0.001
Rod nuclei, per 50 μm	98.5 ± 1.7 (n = 196; 3 mice)	78.4 ± 1.4 (n = 196; 3 mice)	<0.001
ROS length, μm	21.3 ± 0.2 (n = 196; 3 mice)	19.3 ± 0.3 (n = 196; 3 mice)	<0.001
ROS diameter, μm	1.53 ± 0.01 (n = 2335; 3 mice)	1.46 ± 0.01 (n = 2134; 3 mice)	<0.001
Opsin level, pmol/retina	472.5 ± 19.3 (n = 4)	230.7 ± 38.2 (n = 4)	<0.002

Data from light microscopy were averaged across all 14 analyzed retina locations (7 dorsal and 7 ventral). ROS diameter was measured by TEM in ultrathin cross-sections, including 1000 μm of retinal length, starting approximately 500 μm lateral to the optic nerve. The total number of measured profiles is given. Values are means ± SEM.