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Domain structure of major mammalian and worm BH3-only proteins. In addition to the BH3 domain, the C-terminal trans-membrane domain (TM), and other membrane targeting hydrophobic sequences are indicated. MTD, indicates mitochondrial targeting domain. The caspase cleavage sites in BID and MCL-1S and the phosphorylation site in the BH3 domain of BAD are indicated.
