Table 4.

Influence of pharmacogenetic factors on therapeutic warfarin dose in pooled African-American patients (n = 241)

Factor		Effect on warfarin dose
Age in years, mean (SD)	58 (16)	−6% per decade
BSA, m2, mean (SD)	2.1 (0.4)	24% per 0.5m2
Percent Smokers	20%	13%
Percent Using Amiodarone	3%	−16%
CALU Allele frequency	0.14	11% per allele
CYP2C9 *2 Allele Frequency	0.04	−20% per allele
CYP2C9 *3 Allele Frequency	0.01	−34% per allele
VKORC1 3673A Frequency	0.11	−24% per allele
Percent with indication of DVT or PE	43%	2%
Target INR	2.5 (0.13)	4% per 0.25 increase in target INR

SD = standard deviation; INR = international normalized ratio; BSA = body surface area; m = meter; DVT = deep venous thrombosis; PE = pulmonary embolus