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Inhibition of IL-6-induced Ieq stimulation. Aprotinin (28 μg/ml), a prostasin inhibitor, reduced the amiloride-sensitive Ieq by 61 ± 5%. Magnitude of the IL-6-induced Ieq dropped by 57 ± 2% after 12 h of incubation in aprotinin. IL-6 did not alter Ieq in cells pretreated with aprotinin for 12 h. Values are means ± SE (n = 3). *P < 0.05 vs. control.
