Fig. 5.

Increased baroreflex-independent GABA_A inhibition of the RVLM in pregnant rats. In sinoaortic denervated rats, increases in mean arterial pressure (ΔMAP) and RSNA (ΔRSNA) in response to bilateral blockade of GABA_A receptors (bicuculline, Bic) into the RVLM was greater in P compared with NP rats. Prior blockade of ANG II AT₁ receptors (L158,809; AT1X) in the RVLM attenuated responses to Bic, but differences between NP and P rats persisted. *P ≤ 0.05, greater than in NP rats. †P ≤ 0.05, main effect of AT1X. [From Kvochina et al. (110)].