Fig. 5.

SA-β-Gal activity increases in response to diabetes. Activity of the senescent marker SA-β-Gal is noticeably increased in 14-day diabetic animals. The label is observed primarily in cortical tubules and is not observed to any significant extent at this time point in the glomeruli or endothelial cells. Label is also conspicuously decreased in medullary tubules compared with cortical tubules. Arrows pointing to glomeruli in photos are for comparison purposes. Each photograph represents a separate animal.