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Chronic pyruvate suppresses peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α) but increases PGC1α-related coactivator (PRC). A: dose-response relationship between pyruvate concentration and the change in PGC1α and PRC mRNA. B: PGC1α protein content relative to teEF2 protein content. *Significantly different from NaCl (P < 0.05).
