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. Author manuscript; available in PMC: 2010 Aug 26.
Published in final edited form as: J Am Chem Soc. 2008 Oct 17;130(45):14936–14937. doi: 10.1021/ja8062925

Table 2.

Reductive carboxylation substrate scope.

graphic file with name nihms214589u3.jpg
entrya Aryl Group (Ar) σm/p/σ+b yield (%)c
1 graphic file with name nihms214589t1.jpg b 0 56
2 graphic file with name nihms214589t2.jpg c - 60
3 graphic file with name nihms214589t3.jpg d - 66
4 graphic file with name nihms214589t4.jpg e 0.12 92
5 graphic file with name nihms214589t5.jpg f 0.37 68
6 graphic file with name nihms214589t6.jpg g - 65
7 graphic file with name nihms214589t7.jpg h 0.43 79
8 graphic file with name nihms214589t8.jpg a 0.45/0.48 84
9 graphic file with name nihms214589t9.jpg i 0.45/0.48 81
10 graphic file with name nihms214589t10.jpg j 0.50/0.51 72
11 graphic file with name nihms214589t11.jpg k 0.54/0.61 92
12 graphic file with name nihms214589t12.jpg l - 87
13 graphic file with name nihms214589t13.jpg m 0.66/0.66 61
a

Standard conditions: Ni(acac)2 (10 mol%), CS2CO3 (20 mol%), Et2Zn (250 mol%), 18 h.

b

See reference 9.

c

isolated yield.