Table 6.
Aggregate effect of GEE model on interventions tried on symptom responses after adjusting for patient and symptom characteristics
| Adjusted OR (95% CI) | p value | ||
|---|---|---|---|
| Trial (ATSM vs. P&F) | 0.79 (0.54, 1.16) | 0.2222 | |
| Symptom severity at onseta | 1.55 (1.38, 1.74) | <0.0001 | |
| Symptom duration at onseta | 0.98 (0.91, 1.05) | 0.5139 | |
| Total number of symptoms over thresholda | 1.00 (0.93, 1.08) | 0.9936 | |
| CES-D (16+ vs. less than 16)b | 0.65 (0.43, 0.98) | 0.0379 | |
| Comorbidity (3+ vs. less than 3)b | 0.87 (0.60, 1.27) | 0.4792 | |
| Number of contacts over thresholda | 0.40 (0.34, 0.46) | <0.0001 | |
| Cancer stage (early vs. late)b | 1.51 (0.94, 2.43) | 0.0876 | |
| Cancer site (not lung vs. lung)b | 1.12 (0.73, 1.70) | 0.6069 | |
| Compliance (tried 5+ vs. less than 5)a | 1.72 (1.20, 2.49) | 0.0036 | |
| (Not delivered vs. less than 5) | 1.56 (1.05, 2.31) | 0.0265 | |
| Symptom (vs. weakness) | Anxiety | 1.20 (0.63, 2.29) | <0.0001d |
| Constipation | 0.92 (0.45, 1.89) | ||
| Cough | 1.29 (0.52, 3.16) | ||
| Depression | 0.76 (0.40, 1.41) | ||
| Diarrhea | 1.12 (0.48, 2.62) | ||
| Difficulty remembering | 0.56 (0.30, 1.04) | ||
| Dry mouth | 1.94 (0.75, 4.98) | ||
| Dyspneac | 0.34 (0.16, 0.71) | ||
| Fatiguec | 0.39 (0.22, 0.67) | ||
| Insomnia | 1.07 (0.56, 2.02) | ||
| Nausea/vomiting | 1.30 (0.57, 2.96) | ||
| Pain | 0.65 (0.36, 1.18) | ||
| Peripheral neuropathy | 0.50 (0.25, 1.03) | ||
| Poor appetite | 1.03 (0.57, 1.88) |
a
Covariates for symptom-specific
b
Covariates for patient-specific
c
p<0.05 for comparison to symptom of weakness
d
Overall test of any symptom differences on symptom responses