Table 4.
Proportion Achieving Response and Remission From Baseline BSI-12 Scorea
| Intervention | Usual Care | NNT (95% CI) | P Value | |
|---|---|---|---|---|
| Responseb | ||||
| 6 months | 289/503 (57.46) | 185/501 (36.80) | 4.84 (3.93–6.29) | <0.001 |
| 12 months | 320/503 (63.66) | 224/501 (44.68) | 5.27 (4.18–5.27) | <0.001 |
| 18 months | 325/503 (64.64) | 258/501 (51.47) | 7.59 (5.51–12.22) | <0.001 |
| Remissionc | ||||
| 6 months | 218/503 (43.40) | 138/501 (27.49) | 6.28 (4.83–9.98) | <0.001 |
| 12 months | 259/503 (51.49) | 167/501 (33.28) | 5.5 (4.32–7.55) | <0.001 |
| 18 months | 257/503 (51.06) | 184/501 (36.77) | 7.0 (5.19–10.75) | <0.001 |
Abbreviations: BSI-12, Brief Symptom Inventory; CI, confidence interval; NNT, number needed to treat.
a
Data presented as proportion (percentage) weighted for non-response at each follow-up.
b
Response defined as ≥ 50% reduction on the BSI-12, with all those in remission considered to have responded.
c
Remission defined as a per item BSI-12 score of <0.5 (total score <6).