Skip to main content
. Author manuscript; available in PMC: 2010 Aug 26.
Published in final edited form as: J Infect Dis. 2010 Feb 15;201(4):618–626. doi: 10.1086/649842

Table 3.

Fifteen Top-Ranking Associations of Loci with Rate of Progression to Clinical AIDS (25 Single-Nucleotide Polymorphisms [SNPs]) from the Discovery-Stage Genomewide Association Study (Stage 1)

SNP Rank P qa Replication Pb Chromosome Position, base pair Type Ancestral allele Closest gene
rs6984368 1 8.76 × 10−6 .6834 .158 8 82055464 Intronic G PAG1
rs7006101 22 4.81 × 10−5 .7105 6.58 × 10−2 8 82059755 Synonymous C PAG1
rs16899646 2 1.33 × 10−5 .6834 .114 6 31524899 Intergenic C HCP5
rs1691946 3 1.70 × 10−5 .6834 .995 10 29200463 Intronic G C10orf126
rs1775929 7 2.69 × 10−5 .6834 .881 10 29199354 Intronic T C10orf126
rs1691943 8 2.69 × 10−5 .6834 .881 10 29200842 Intronic G C10orf126
rs1775933 11 3.10 × 10−5 .6834 .844 10 29200882 Intronic G C10orf126
rs11648686 4 1.78 × 10−5 .6834 .175 16 50950897 Intergenic G TOX3
rs4800820 5 2.20 × 10−5 .6834 .710 18 23630471 Intergenic T CDH2
rs9957708 9 2.71 × 10−5 .6834 .523 18 23633388 Intergenic A CDH2
rs7102407 6 2.32 × 10−5 .6834 .828 11 9512693 Intergenic C ZNF143
rs10082685 38 7.89 × 10−5 .7185 .460 11 9500492 Intronic G ZNF143
rs4910466 39 8.28 × 10−5 .7263 4.79 × 10−2 11 9465928 Intronic G ZNF143
rs12332694 10 2.71 × 10−5 .6834 .942 5 79377745 Intronic C THBS4
rs775095 12 3.20 × 10−5 .6834 .346 20 15917077 Intronic T MACROD2
rs4910052 13 3.31 × 10−5 .6834 1.50 × 10−2 11 9411950 Synonymous T IPO7
rs36048375 14 3.31 × 10−5 .6834 1.49 × 10−2 11 9419893 Intronic G IPO7
rs7983751 15 3.37 × 10−5 .6834 .673 13 29992021 Intronic T HMGB1
rs11622505 16 3.46 × 10−5 .6834 .980 14 92387319 Intergenic A GOLGA5
rs17762150 17 3.64 × 10−5 .6834 8.30 × 10−4 1 212191441 Intergenic C PROX1
rs1367951 30 6.69 × 10−5 .7105 5.90 × 10−4 1 212192136 Intergenic A PROX1
rs17762192 34 7.13 × 10−5 .7105 4.80 × 10−4 1 212191750 Intergenic G PROX1
rs2267420 18 3.73 × 10−5 .6834 .220 22 38678466 Intronic A GRAP2
rs498280 19 3.84 × 10−5 .6834 7.88 × 10−2 7 105188251 3′_utr C ATXN7L1
rs17050206 20 3.95 × 10−5 .6834 .700 4 139372068 Intronic C SLC7A11

NOTE. Boldface type SNPs in adjacent rows represent linked SNPs (r2 > 0.09).

a

P values corrected for false discovery rate (q values).

b

P values for AIDS 1987 diagnoses in the replication cohort, uncorrected for multiple tests.