Table 7. Time course of clinical signs after botulinum toxin type A injection (5 estimated MLD50/mouse).
Mouse # | Before 4 h | 4 h | 5 h | 5.5 h | 6 h | 6.5 h | 7 h | 7.5 h | 8 h | 24 h |
1 | No sign | A | A | A | A | A | A | A | A | A |
2 | No sign | S | S | P | P | P | P | P | M | D |
3 | No sign | S | S | P | P | P | P | M | M | D |
4 | No sign | S | S | S | S | S | S | S | P | D |
5 | No sign | S | S | P | P | P | P | M | M | D |
6 | No sign | P | P | P | M | M | D | D | D | D |
7 | No sign | S | P | P | P | P | M | M | M | D |
8 | No sign | S | S | S | P | P | P | P | M | D |
A: Alive; S: Skinny; P: Paralyzed; M: Motionless; D: Dead
The indicated times correspond to the time after botulinum toxin injection