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. 2010 Aug 26;5(8):e12424. doi: 10.1371/journal.pone.0012424

Figure 2. The biological activity of trastuzumab on EAC cell lines.

Figure 2

The HER-2 positive EAC cell lines treated with increasing concentrations of trastuzumab for 24 and 72 hours, progressively show decreased cell viability in both OE33 and OE19 (A and B). SW620 (HER-2 negative colon cell line) shows no sensitivity to trastuzumab (C) (Data are means ± SD of six experimental points from two independent experiments). Apoptosis levels as measured in EAC cell lines treated for 48 hours with 10 µg of trastuzumab does not show any difference between treated and not treated cells (Violet area D =  trastuzumab treated cells, Green line D =  not treated cells, dotted line D =  isotype control).