Table 2.

Univariable and multivariable associations of obesity and diabetes SNPs with small for gestational age at term (allelic and genotypic) data

								Univariable analysis				Multivariable analysis*
Gene	SNP	alleles	Minor allele	Risk allele associated with SGA in ABC samples	Risk allele associated with obesity/diabetes	Minor allele frequency	Minor allele homozygote frequency	genotypic p-value	allelic p-value	Odds ratio	95% CI	Genotypic p-value	allelic p-value	Odds ratio	95% CI
FTO	rs9939609	AT	A	A	A (obesity)	33.8	11.4	0.03	0.42	1.11	0.86-1.43	0.40	0.63	1.07	0.80-1.44
JAZF1	rs864745	AG	G	G	A (diabetes)	48.3	26.7	0.09	0.64	1.06	0.83-1.36	0.26	0.98	1	0.75-1.32
KCNJ11	rs5219	CT	T	T	T (diabetes)	33.7	12.3	0.02	0.03	1.32	1.03-1.70	0.061	0.03	1.36	1.02-1.82
LPL	rs3200218	GA	G	A	A (obesity)	26.3	5.5	0.20	0.06	0.76	0.56-1.02	0.21	0.09	0.74	0.53-1.04
PFKP	rs6602024	GA	A	G	A (obesity)	12.0	0	0.08	0.13	0.73	0.49-1.10	0.03	0.06	0.64	0.40-1.02
PTER	rs10508503	CT	T	C	C (obesity)	9.8	0.5	0.04	0.06	0.64	0.41-1.02	0.07	0.04	0.58	0.34-0.98
SEC16B	rs10913469	TC	C	T	C (obesity)	18.0	1.6	0.05	0.82	0.96	0.70-1.33	0.01	0.22	0.79	0.54-1.15
BDNF	rs6265	AG	A	A	G (obesity)	16.2	2.2	0.11	0.10	1.33	0.95-1.85	0.10	0.07	1.43	0.98-2.09
BDNF	rs925946	GT	T	G	T (obesity)	30.7	11.1	0.01	0.08	0.79	0.61-1.02	0.043	0.06	0.75	0.56-1.01

*Multivariable model controls for gestational age, gender, socio-economic status, age mother left school, marital status, attendance at antenatal classes, primiparity, maternal smoking during pregnancy, marijuana use during pregnancy, maternal height and weight, maternal age at index pregnancy and maternal hypertension