Table 3.
Univariable and multivariable associations of obesity and diabetes SNPs with small for gestational age at term (genotype data)
| SNP | genotype | n | Univariable OR | Multivariable* OR |
|---|---|---|---|---|
| rs9939609 | A | 61 | 0.91 (0.50 - 1.64) | 0.96 (0.47 - 1.94) |
| FTO | AT | 265 | 1.54 (1.07 - 2.22) | 1.30 (0.85 - 1.99) |
| T | 218 | Ref | Ref | |
| rs864745 | A | 145 | Ref | Ref |
| JAZF1 | AG | 346 | 1.57 (1.03 - 2.39) | 1.43 (0.88 - 2.32) |
| G | 136 | 1.18 (0.73 - 1.91) | 1.04 (0.59 - 1.83) | |
| rs5219 | C | 223 | Ref | Ref |
| KCNJ11 | CT | 252 | 1.64 (1.13 - 2.37) | 1.50 (0.98 - 2.31) |
| T | 76 | 1.59 (0.94 - 2.69) | 1.90 (1.04 - 3.50) | |
| rs6265 | A | 17 | 2.84 (1.03 - 7.87) | 3.29 (1.08 - 9.99) |
| BDNF | AG | 142 | 1.17 (0.79 - 1.74) | 1.18 (0.74 - 1.90) |
| G | 347 | Ref | Ref | |
| rs925946 | G | 232 | Ref | Ref |
| BDNF | T | 66 | 0.84 (0.48 -1.46) | 0.71 (0.38 - 1.34) |
| GT | 249 | 0.58 (0.40 -0.83) | 0.58 (0.38 - 0.89) | |
| rs6602024 | A | 0 | undefined | undefined |
| PFKP | GA | 116 | 0.68 (0.44 - 1.04) | 0.57 (0.35 - 0.95) |
| G | 435 | Ref | Ref | |
| rs10508503 | C | 447 | Ref | Ref |
| PTER | CT | 82 | 0.55 (0.33 - 0.91) | 0.51 (0.28 - 0.91) |
| T | 3 | 2.49 (0.22 - 27.7) | 1.19 (0.09 -16.58) | |
| rs10913469 | C | 13 | 2.94 (0.89 - 9.73) | 2.54 (0.65 - 9.97) |
| SEC16B | TC | 367 | 0.74 (0.50 - 1.09) | 0.56 (0.35 - 0.89) |
| T | 158 | Ref | Ref |
* Multivariable model controls for gestational age, gender, socio-economic status, age mother left school, marital status, attendance at antenatal classes, primiparity, maternal smoking during pregnancy, marijuana use during pregnancy, maternal height and weight, maternal age at index pregnancy and maternal hypertension.