Figure 5.

Effect of the finite sampling noise on the parameter estimation of E. coli RNA dynamics model. Normalized objective function contours of the DFD-PDF method for SSA realizations of 10,000 (A), 5000 (B), and 1000 (C). The parameter values k₂ and k₃ were varied between 0.1 and 1 while keeping the value of k₁ at its original value. The normalization was done with respect to the optimal solution from each case, where the white circles represent the extrema on the normalized objective function plane.