Figure 1.

Survival Dimensionality Reduction (SDR) process. Step 1, survival estimates are calculated in the whole population by the Kaplan-Meier method. Step 2, survival estimates are computed in each multidimensional cell. Step 3, time-point differences in survival estimates between the whole population and each multidimensional cell are calculated. Step 4, time-point differences are normalized to 1 to take into account negative values and then averaged via the geometric mean (GM). Step 5, individual data from multidimensional cells with GM ≤ 1 ("high-risk") are pooled and compared via log rank-test statistic, to individual data from multidimensional cells with GM > 1 ("low-risk").