Table 2. The association of known risk alleles for T2D by race/ethnicity.a b .
| SNP | Risk Allelec | Chr. | NearestGene | European Americans533 cases1,006 controls | African Americans1,077 cases1,469 controls | Latinos2,220 cases2,184 controls | Japanese Americans1,736 cases1,761 controls | Native Hawaiians576 cases983 controls | Pooled6,142 cases7,403 controls | P value | Phet d | |
| rs10923931 | T | 1 | NOTCH2 | OR(95%CI) | 0.84 (0.64–1.10) | 1.10 (0.97–1.25) | 1.17 (1.01–1.35) | 1.00 (0.70–1.44) | 0.76 (0.50–1.15) | 1.06 (0.98–1.16) | 0.16 | 0.086 |
| RAF | 0.12 | 0.29 | 0.09 | 0.02 | 0.05 | 0.11 | ||||||
| rs7578597 | T | 2 | THADA | OR(95%CI) | 1.42 (1.06–1.91) | 1.04 (0.90–1.19) | 1.12 (0.93–1.35) | 1.10 (0.68–1.78) | 1.65 (1.01–2.70) | 1.13 (1.02–1.25) | 0.016 | 0.21 |
| RAF | 0.90 | 0.75 | 0.94 | 0.99 | 0.97 | 0.91 | ||||||
| rs1801282 | C | 3 | PPARG | OR(95%CI) | 1.26 (0.95–1.68) | 1.95 (1.30–2.92) | 1.03 (0.89–1.19) | 1.05 (0.82–1.36) | 1.14 (0.84–1.55) | 1.13 (1.02–1.26) | 0.018 | 0.048 |
| RAF | 0. 89 | 0.97 | 0.90 | 0.96 | 0.93 | 0.93 | ||||||
| rs4607103 | C | 3 | ADAMTS9 | OR(95%CI) | 1.11 (0.92–1.34) | 1.03 (0.91–1.18) | 0.99 (0.89–1.08) | 1.05 (0.94–1.17) | 0.98 (0.82–1.16) | 1.02 (0.97–1.08) | 0.45 | 0.78 |
| RAF | 0.73 | 0.70 | 0.69 | 0.61 | 0.72 | 0.68 | ||||||
| rs4402960 | T | 3 | IGF2BP2 | OR(95%CI) | 1.02 (0.85–1.23) | 1.14 (1.01–1.28) | 1.05 (0.95–1.16) | 1.24 (1.11–1.38) | 1.17 (0.99–1.39) | 1.13 (1.07–1.19) | 2.2×10−5 | 0.26 |
| RAF | 0.31 | 0.49 | 0.27 | 0.30 | 0.27 | 0.33 | ||||||
| rs10010131 | G | 4 | WFS1 | OR(95%CI) | 1.18 (0.99–1.40) | 0.94 (0.83–1.07) | 1.15 (1.04–1.27) | 1.45 (0.98–2.13) | 1.27 (1.03–1.56) | 1.11 (1.04–1.19) | 1.8×10−3 | 0.032 |
| RAF | 0.59 | 0.66 | 0.71 | 0.98 | 0. 81 | 0.76 | ||||||
| rs7754840 | C | 6 | CDKAL1 | OR(95%CI) | 1.26 (1.05–1.50) | 1.03 (0.92–1.16) | 1.09 (0.99–1.19) | 1.37 (1.24–1.52) | 1.39 (1.19–1.62) | 1.20 (1.13–1.26) | 4.1×10−11 | 6.2×10−4 |
| RAF | 0.29 | 0.55 | 0.31 | 0.40 | 0.52 | 0.40 | ||||||
| rs864745 | T | 7 | JAZF1 | OR(95%CI) | 0.98 (0.83–1.16) | 1.16 (1.01–1.32) | 1.30 (1.19–1.43) | 1.19 (1.05–1.35) | 1.13 (0.93–1.36) | 1.20 (1.13–1.27) | 1.3×10−9 | 0.054 |
| RAF | 0.51 | 0.73 | 0.61 | 0.77 | 0.75 | 0.68 | ||||||
| rs13266634 | C | 8 | SLC30A8 | OR(95%CI) | 1.28 (1.06–1.54) | 1.21 (0.99–1.48) | 1.11 (1.00–1.23) | 1.18 (1.06–1.31) | 1.04 (0.88–1.22) | 1.15 (1.08–1.22) | 9.7×10−6 | 0.47 |
| RAF | 0.68 | 0. 89 | 0.75 | 0.60 | 0.62 | 0.72 | ||||||
| rs2383208 | A | 9 | CDKN2B | OR(95%CI) | 1.35 (1.07–1.69) | 1.14 (0.98–1.33) | 1.15 (1.01–1.31) | 1.26 (1.13–1.40) | 1.02 (0.85–1.22) | 1.18 (1.11–1.26) | 2.1×10−7 | 0.27 |
| RAF | 0. 81 | 0. 81 | 0. 85 | 0.56 | 0.74 | 0.75 | ||||||
| rs1111875 | C | 10 | HHEX | OR(95%CI) | 0.93 (0.78–1.11) | 1.10 (0.95–1.26) | 1.03 (0.94–1.13) | 1.21 (1.08–1.36) | 0.93 (0.78–1.11) | 1.07 (1.01–1.13) | 0.028 | 0.037 |
| RAF | 0.61 | 0.74 | 0.63 | 0.28 | 0.28 | 0.52 | ||||||
| rs7903146 | T | 10 | TCF7L2 | OR(95%CI) | 1.55 (1.29–1.87) | 1.32 (1.16–1.51) | 1.31 (1.19–1.45) | 1.74 (1.38–2.20) | 1.12 (0.90–1.40) | 1.36 (1.27–1.45) | 1.1×10−19 | 0.068 |
| RAF | 0.27 | 0.28 | 0.23 | 0.04 | 0.14 | 0.19 | ||||||
| rs12779790 | G | 10 | CDC123 | OR(95%CI) | 1.02 (0.82–1.28) | 1.09 (0.92–1.29) | 1.19 (1.06–1.33) | 1.01 (0.88–1.15) | 1.16 (0.95–1.41) | 1.10 (1.03–1.18) | 5.9×10−3 | 0.36 |
| RAF | 0.17 | 0.14 | 0.17 | 0.17 | 0.18 | 0.17 | ||||||
| rs2237895e | C | 11 | KCNQ1 | OR(95%CI) | 0.98 (0.82–1.16) | 1.04 (0.90–1.21) | 1.15 (1.05–1.28) | 1.12 (0.98–1.27) | 1.16 (0.97–1.39) | 1.11 (1.04–1.18) | 7.8×10−4 | 0.17 |
| RAF | 0.42 | 0.20 | 0.40 | 0.35 | 0.33 | 0.34 | ||||||
| rs2237897e | C | 11 | KCNQ1 | OR(95%CI) | 0.86 (0.59–1.26) | 1.13 (0.90–1.42) | 1.23 (1.09–1.39) | 1.26 (1.11–1.44) | 1.06 (0.86–1.31) | 1.21 (1.13–1.30) | 3.2×10−7 | 0.10 |
| RAF | 0.95 | 0.92 | 0.76 | 0.62 | 0.78 | 0.79 | ||||||
| rs5219 | T | 11 | KCNJ11 | OR(95%CI) | 1.24 (1.05–1.47) | 1.03 (0.84–1.26) | 1.09 (1.00–1.20) | 1.26 (1.13–1.40) | 1.03 (0.88–1.21) | 1.15 (1.08–1.21) | 3.3×10−6 | 0.13 |
| RAF | 0.35 | 0.09 | 0.37 | 0.35 | 0.37 | 0.31 | ||||||
| rs7961581 | C | 12 | TSPAN8 | OR(95%CI) | 1.03 (0.86–1.24) | 0.92 (0.80–1.06) | 1.03 (0.93–1.15) | 1.00 (0.88–1.14) | 1.12 (0.94–1.33) | 1.01 (0.95–1.08) | 0.71 | 0.51 |
| RAF | 0.29 | 0.23 | 0.21 | 0.21 | 0.29 | 0.23 | ||||||
| rs8050136 | A | 16 | FTO | OR(95%CI) | 0.89 (0.75–1.06) | 1.07 (0.95–1.20) | 1.02 (0.92–1.12) | 1.04 (0.92–1.18) | 1.01 (0.84–1.21) | 1.02 (0.96–1.08) | 0.48 | 0.68 |
| RAF | 0.41 | 0.43 | 0.27 | 0.20 | 0.23 | 0.30 | ||||||
| rs4430796 | G | 17 | HNF1B | OR(95%CI) | 0.96 (0.82–1.14) | 1.10 (0.97–1.25) | 0.96 (0.88–1.05) | 1.18 (1.06–1.32) | 1.09 (0.92–1.30) | 1.05 (1.00–1.11) | 0.058 | 0.043 |
| RAF | 0.50 | 0.65 | 0.42 | 0.36 | 0.31 | 0.45 |
a
Odds ratios (and 95% confidence intervals) for allele dosage effects are adjusted for age (quartiles), BMI (quartiles), sex, and ethnicity (in pooled analysis).
b
Ethnic specific risk allele frequencies (RAF) calculated for each SNP.
c
NCBI build 36 (forward strand).
d
Phet = P value for heterogeneity of allelic effects across ethnic groups (4 df test).
e
rs2237895 and rs2237897 adjusted for each other.