Table 3. The association of the total risk score with T2D risk by racial/ethnic population.^a .

		European Americans	African Americans	Latinos	Japanese Americans	Native Hawaiians	Pooled
Total Risk alleles, Mean (range)		18.8 (10–27)	20.2 (11–27)	18.6 (10–28)	17.2 (10–26)	18.1 (10–26)	18.5 (10–28)
Per allele additive model
n (cases/controls)		533/1,006	1,077/1,469	2,220/2,184	1,736/1,761	576/983	6,142/7,403
OR(95% CI)b c		1.11 (1.06–1.17)	1.09 (1.05–1.12)	1.12 (1.09–1.14)	1.20 (1.17–1.24)	1.10 (1.06–1.15)	1.13 (1.11–1.15)
P-value		1.2×10−5	3.0×10−6	7.5×10−19	7.0×10−32	1.2×10−5	4.7×10−59
P-value vs. European Americans		Ref.	0.43	0.76	0.007	0.86
Quartiles of Risk Alleles d
Q1	n (cases/controls)	69/196	206/360	362/464	267/441	119/251	1,023/1,712
	OR(95% CI)	1.00(ref)	1.00(ref)	1.00(ref)	1.00(ref)	1.00(ref)	1.00(ref)
Q2	n (cases/controls)	112/273	273/437	520/605	424/518	150/307	1,479/2,140
	OR(95% CI)	1.17 (0.79–1.73)	1.10 (0.86–1.40)	1.17 (0.97–1.42)	1.39 (1.12–1.72)	1.11 (0.81–1.52)	1.21 (1.08–1.35)
	P-value	0.44	0.45	0.10	3.2×10−3	0.51	8.4×10−4
Q3	n (cases/controls)	170/281	353/391	626/587	297/306	167/259	1,613/1,824
	OR(95% CI)	1.52 (1.05–2.21)	1.59 (1.25–2.01)	1.50 (1.25–1.81)	1.85 (1.46–2.36)	1.39 (1.02–1.90)	1.61 (1.44–1.80)
	P-value	0.027	1.3×10−4	2.1×10−5	5.4×10−7	0.039	4..2×10−17
Q4	n (cases/controls)	182/256	245/281	712/528	748/496	140/166	2,027/1,727
	OR(95% CI)	1.88 (1.29–2.74)	1.58 (1.22–2.04)	1.99 (1.65–2.40)	3.06 (2.48–3.77)	2.09 (1.49–2.94)	2.17 (1.95–2.42)
	P-value	9.3×10−4	5.3×10−4	7.6×10−13	7.9×10−26	2.0×10−5	4.6×10−44

^aOdds ratios (and 95% confidence intervals) adjusted for age (quartiles), BMI (quartiles), sex, and ethnicity (in pooled analysis).

^bP = 3.8×10⁻⁴ for heterogeneity of allelic effects across ethnic groups (4 df test).

^cP≤0.02 for each ethnic group for the comparison with Japanese Americans.

^dQuartiles are defined separately for each population.