Table 3.

Fracture hazard ratios by cumulative PDC

	Fracture type
	All sites	Hip	Nonhip	Humerus	Vertebral	Nonvertebral	Distal forearm
Unadjusted hazard ratios
Cumulative PDC
0–19%	Referent	Referent	Referent	Referent	Referent	Referent	Referent
20–39%	0.84 (0.72–0.97)	0.80 (0.62–1.04)	0.90 (0.77–1.06)	0.52 (0.33–0.82)	0.94 (0.75–1.19)	0.80 (0.67–0.95)	1.22 (0.90–1.67)
40–59%	0.81 (0.69–0.95)	0.78 (0.59–1.04)	0.83 (0.69–1.00)	0.60 (0.38–0.97)	0.77 (0.59–1.02)	0.86 (0.71–1.04)	0.91 (0.62–1.33)
60–79%	0.82 (0.71–0.95)	0.72 (0.55–0.94)	0.83 (0.71–0.99)	0.67 (0.45–1.01)	0.82 (0.64–1.05)	0.79 (0.67–0.95)	0.91 (0.64–1.27)
80–100%	0.74 (0.67–0.82)	0.72 (0.60–0.87)	0.76 (0.67–0.85)	0.56 (0.42–0.75)	0.67 (0.56–0.80)	0.76 (0.67–0.86)	0.94 (0.75–1.20)
Multivariate adjusted hazard ratiosa
Cumulative PDC
0–19%	Referent	Referent	Referent	Referent	Referent	Referent	Referent
20–39%	0.84 (0.73–0.97)	0.82 (0.63–1.06)	0.90 (0.76–1.06)	0.52 (0.33–0.82)	0.94 (0.75–1.19)	0.80 (0.67–0.96)	1.22 (0.89–1.66)
40–59%	0.83 (0.7–0.98)	0.81 (0.61–1.08)	0.85 (0.71–1.03)	0.61 (0.38–0.98)	0.81 (0.62–1.07)	0.88 (0.73–1.06)	0.92 (0.63–1.34)
60–79%	0.86 (0.74–1.00)	0.76 (0.58–0.99)	0.87 (0.74–1.04)	0.69 (0.46–1.04)	0.88 (0.69–1.13)	0.82 (0.69–0.98)	0.92 (0.65–1.29)
80–100%	0.78 (0.7–0.87)	0.77 (0.64–0.92)	0.80 (0.71–0.91)	0.57 (0.42–0.76)	0.74 (0.62–0.88)	0.79 (0.70–0.89)	0.95 (0.75–1.21)

The composite all-site outcome includes hip, nonhip femur, humerus, tibia/fibula, proximal forearm, distal forearm, clavicle/scapula, sternum, spine, and pelvis fractures. Hip fractures are excluded from the nonhip outcome, and vertebral fractures are excluded from the nonvertebral outcome. 

^aEstimates are adjusted for the covariates presented in Table 1.