Table 5.

Fracture hazard ratios by instantaneous PDC

	Fracture type
	All sites	Hip	Nonhip	Humerus	Vertebral	Nonvertebral	Distal forearm
Unadjusted hazard ratios
Instantaneous PDC
0–19%	Referent	Referent	Referent	Referent	Referent	Referent	Referent
20–39%	0.87 (0.64–1.18)	0.87 (0.51–1.48)	0.91 (0.64–1.29)	1.07 (0.50–2.29)	1.02 (0.64–1.64)	0.87 (0.60–1.25)	0.75 (0.35–1.59)
40–59%	0.80 (0.65–0.98)	0.68 (0.46–0.99)	0.83 (0.66–1.05)	0.36 (0.16–0.81)	0.90 (0.65–1.24)	0.73 (0.57–0.94)	0.76 (0.47–1.22)
60–79%	0.83 (0.68–1.01)	0.78 (0.54–1.11)	0.87 (0.70–1.09)	0.82 (0.47–1.42)	0.80 (0.58–1.12)	0.89 (0.71–1.12)	0.86 (0.55–1.34)
80–100%	0.78 (0.71–0.86)	0.75 (0.63–0.88)	0.79 (0.71–0.88)	0.72 (0.56–0.95)	0.66 (0.56–0.78)	0.82 (0.73–0.92)	0.88 (0.71–1.09)
Multivariate adjusted hazard ratiosa
Instantaneous PDC
0–19%	Referent	Referent	Referent	Referent	Referent	Referent	Referent
20–39%	0.91 (0.67–1.23)	0.92 (0.54–1.56)	0.95 (0.67–1.34)	1.11 (0.52–2.37)	1.07 (0.67–1.72)	0.90 (0.63–1.30)	0.77 (0.36–1.64)
40–59%	0.84 (0.69–1.04)	0.73 (0.50–1.08)	0.87 (0.69–1.10)	0.37 (0.16–0.85)	0.96 (0.70–1.32)	0.77 (0.60–0.99)	0.77 (0.48–1.25)
60–79%	0.87 (0.72–1.07)	0.83 (0.58–1.19)	0.92 (0.73–1.15)	0.86 (0.49–1.48)	0.87 (0.62–1.21)	0.93 (0.74–1.17)	0.87 (0.56–1.37)
80–100%	0.83 (0.75–0.91)	0.80 (0.67–0.94)	0.84 (0.75–0.94)	0.75 (0.57–0.98)	0.72 (0.61–0.85)	0.85 (0.76–0.96)	0.90 (0.72–1.11)

The composite all site outcome includes hip, nonhip femur, humerus, tibia/fibula, proximal forearm, distal forearm, clavicle/scapula, sternum, spine, and pelvis fractures. Hip fractures are excluded from the nonhip outcome and vertebral fractures are excluded from the nonvertebral outcome. 

^aEstimates are adjusted for the covariates presented in Table 1.