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. 2010 Apr 28;95(7):3368–3376. doi: 10.1210/jc.2010-0195

Figure 5.

Figure 5

Evolution of low-affinity forms of DBP enhances monocyte responses to vitamin D. Schematic representation of the impact of DBP genotype (Gc type) on monocyte responses to 25OHD3, the major circulating form of vitamin D is shown. The left part of the panel shows primary DBP peptide sequence variations corresponding to the three major GC forms. The right part of the panel shows proposed variations in sensitivity to the immunomodulatory effects of 25OHD3 for low- or high-affinity Gc forms.