Skip to main content
. 2010 Jul 1;42(8):533–546. doi: 10.3858/emm.2010.42.8.054

Figure 5.

Figure 5

AHR and non-eosinophilic lung inflammation are impaired by the absence of IL-12Rβ2-mediated signaling in the Th2 asthma model. Evaluations (n = 5 each group) were performed twice after allergen challenge. *, P < 0.05 compared to mice sensitized with PBS; **, P < 0.05 versus the other groups. (A) Methacholine AHR of IL-12Rβ2-/- and WT (C57BL/6) mice 24 h after the final allergen challenge. (B) BAL cellularity (left panel) and representative lung histology 48 h after the final allergen challenge. (H&E staining, original magnification ×200). a, WT_PBS; b, IL-12Rβ2-/-_PBS; c, WT_OVA/alum; d, IL-12Rβ2-/-_OVA/alum. (C) The levels of IP-10 (left panel) and TGF-β1 (right panel) in the BAL fluids of IL-12Rβ2-/- and WT mice 6 h after three rounds of allergen challenge. (D) IFN-γ-producing CD4+ and CD8+ T cells in IL-12Rβ2-/- and WT mice 6 h after three rounds of allergen challenge. (E) Levels of IP-10 (left panel), IL-12 (middle panel), and TGF-β1 (right panel) in the IL-12Rβ2-/- and WT mice 48 h after the final allergen challenge.