Figure 3.

Anti-GBM antibody alters the morphology of the glomerular endothelium within ten minutes. The structure of the glomerular endothelium was assessed using transmission electron microscopy. A: Glomerular capillary of a mouse shortly after receiving NSG, showing the typical discontinuous morphology of the glomerular endothelium (arrows) lining the capillary. B: Glomerular capillary of a mouse ten minutes after receiving anti-GBM antibody. The endothelial structure is markedly altered, with numerous protrusions into the vascular lumen (arrowheads). Scale bar = 2 μm.