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. 2010 Sep;177(3):1187–1197. doi: 10.2353/ajpath.2010.091289

Figure 5.

Figure 5

FeTPPs blocked activation of p38 MAPK apoptosis pathway. A: After one day of intravitreal NMDA injection, Western blot analysis showed 1.8-fold increase in p38 MAPK phosphorylation in rat retina lysate of NMDA-injected retinas compared with NMLA controls (n = 5–6). B: Western blot analysis of rat retina lysate showed a 2.3-fold increase in cleaved PARP expression in NMDA-injected retinas compared with NMLA controls (n = 4). Treatment of animals with FeTPPs (100 μg/eye) reversed these effects in NMDA-injected retinas but did not affect NMLA controls. There was a significant difference as compared with rest of the groups at *P < 0.05.