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. 2010 Sep;177(3):1198–1213. doi: 10.2353/ajpath.2010.091108

Figure 12.

Figure 12

Regulation of phosphorylated p38 (p-p38), and phosphorylated ERK (p-ERK) in dissected RPE sheets from mice treated with HQ (0.8%) in drinking water for seven months. Protein was extracted from RPE sheets (n = 6 eyes/group). A: p-p38 protein expression determined by Western blot. Top: Western blot from a representative experiment. Numbers on the left represent protein molecular mass in kilodaltons. p-p38 protein expression was normalized to total p38 protein. Bottom: Data are the average results from six eyes. Data are expressed as percentage of control and shown are mean results ± SE. ***P < 0.001 versus control. B: Ratio p38/GAPDH protein expression evaluated by Western blot. Top: Western blot from a representative experiment. Numbers on the left represent protein molecular mass in kilodaltons. Bottom: Data are the average results from six eyes. Data are expressed as percentage of control and shown are mean results ± SE. C: pERK protein expression determined by Western blot. Top: Western blot from a representative experiment. Numbers on the left represent protein molecular mass in kilodaltons. p-ERK protein expression was normalized to total ERK protein. Bottom: Data are the average results from six eyes. Data are expressed as percentage of control and shown are mean results ± SE. ***P < 0.001 versus control. D: Ratio ERK/GAPDH protein expression evaluated by Western blot. Top: Western blot from a representative experiment. Numbers on the left represent protein molecular mass in kilodaltons. Bottom: Data are the average results from six eyes. Data are expressed as percentage of control and shown are mean results ± SE.