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. Author manuscript; available in PMC: 2010 Aug 27.
Published in final edited form as: N Engl J Med. 2009 Jul 16;361(3):255–263. doi: 10.1056/NEJMoa0809437

Table 2.

Mixed Models of APOE e4 Carriers and Noncarriers

AVLT MMSE COWAT JLO
Estimate SE P Estimate SE P Estimate SE P Estimate SE P
Fixed Effects
Intercept 9.19 0.16 <.0001 29.52 0.05 <.0001 44.57 0.60 <.0001 24.79 0.20 <.0001
Carrieri −0.34 0.26 0.1973 0.02 0.09 0.8577 −0.26 0.97 0.7927 0.29 0.33 0.3719
Agei1-60 −0.0853 0.0254 0.0008 −0.0234 0.0102 0.0221 −0.3979 0.0809 <.0001 −0.1118 0.0342 0.0011
Carrieri × (Agei1-60) 0.0381 0.0379 0.3145 0.0277 0.0150 0.0657 −0.0189 0.1213 0.876 0.1360 0.0510 0.0078
 (Agei1-60)2 0.0021 0.0013 0.1076 0.0006 0.0005 0.2744 0.0078 0.0041 0.0586 0.0017 0.0016 0.2842
Carrieri × (Agei1-60)2 0.0031 0.0020 0.1311 0.0000 0.0008 0.9636 0.0035 0.0065 0.5897 0.0000 0.0025 0.9964
Ageij-60 0.0408 0.0244 0.0953 0.0060 0.0101 0.5511 0.3406 0.0743 <.0001 0.0692 0.0331 0.0371
Carrieri × (Ageij-60) −0.0685 0.0351 0.0511 −0.0309 0.0145 0.0336 −0.0233 0.1065 0.8268 −0.1257 0.0479 0.0088
 (Ageij-60)2 −0.0013 0.0012 0.2804 −0.0008 0.0005 0.0862 −0.0116 0.0035 0.0011 −0.0020 0.0015 0.1763
Carrieri × (Ageij-60)2 −0.0041 0.0018 0.0253 −0.0002 0.0007 0.7508 −0.0031 0.0055 0.5709 −0.0006 0.0022 0.7775
Random Effects
Intercept 6.55 0.41 <.0001 0.60 0.06 <.0001 102.40 6.01 <.0001 9.42 0.62 <.0001
Residual 3.61 0.13 <.0001 0.64 0.03 <.0001 32.42 1.19 <.0001 4.85 0.20 <.0001

AVLT = Auditory Verbal Learning Test (Long Term Memory Score); MMSE = Mini Mental Status Examination; COWAT = Controlled Oral Word Association Test; JLO = Judgement of Line Orientation; SE = Standard Error