Table 3.

Mixed Models of APOE e4 Homozygotes, Heterozygotes, and Noncarriers

	AVLT			MMSE			COWAT			JLO
	Estimate	SE	P	Estimate	SE	P	Estimate	SE	P	Estimate	SE	P
Fixed Effects
Intercept	9.19	0.16	<.0001	29.52	0.05	<.0001	44.57	0.60	<.0001	24.79	0.20	<.0001
Heteroi	−0.32	0.29	0.2732	0.05	0.10	0.6066	−1.34	1.09	0.2183	0.37	0.36	0.3057
Homoi	−0.42	0.42	0.3178	−0.08	0.14	0.5936	2.74	1.57	0.0812	0.12	0.54	0.8284
Agei1-60	−0.0853	0.0254	0.0008	−0.0234	0.0102	0.0222	−0.3979	0.0809	<.0001	−0.1117	0.0342	0.0011
Heteroi × (Agei1-60)	0.0020	0.0420	0.9622	0.0274	0.0167	0.1022	−0.0611	0.1337	0.6476	0.1248	0.0564	0.0271
Homoi × (Agei1-60)	0.0575	0.0658	0.3823	0.0241	0.0247	0.329	0.0879	0.2243	0.6953	0.1548	0.0870	0.0754
(Agei1-60)2	0.0021	0.0013	0.1069	0.0006	0.0005	0.2705	0.0078	0.0041	0.0587	0.0017	0.0016	0.2843
Heteroi × (Agei1-60)2	0.0017	0.0022	0.4376	−0.0010	0.0009	0.2576	0.0033	0.0070	0.639	−0.0021	0.0027	0.4405
Homoi × (Agei1-60)2	0.0052	0.0042	0.2158	0.0032	0.0016	0.0497	0.0007	0.0141	0.9582	0.0065	0.0052	0.2091
Ageij-60	0.0408	0.0244	0.0946	0.0060	0.0101	0.5546	0.3407	0.0743	<.0001	0.0691	0.0331	0.0371
Heteroi × (Ageij-60)	−0.0279	0.0394	0.479	−0.0315	0.0163	0.0525	0.0138	0.1196	0.9082	−0.1200	0.0532	0.0243
Homoi × (Ageij-60)	−0.1457	0.0497	0.0034	−0.0273	0.0206	0.184	−0.0930	0.1509	0.5381	−0.1257	0.0702	0.0734
(Ageij-60)2	−0.0013	0.0012	0.2793	−0.0008	0.0005	0.0841	−0.0116	0.0035	0.0011	−0.0020	0.0015	0.1762
Heteroi × (Ageij-60)2	−0.0027	0.0020	0.1754	0.0007	0.0008	0.3641	−0.0006	0.0060	0.9253	0.0014	0.0024	0.5658
Homoi × (Ageij-60)2	−0.0083	0.0032	0.0087	−0.0034	0.0013	0.01	−0.0123	0.0096	0.197	−0.0080	0.0039	0.0431
Random Effects
Intercept	6.53	0.41	<.0001	0.60	0.06	<.0001	101.97	6.00	<.0001	9.46	0.62	<.0001
Residual	3.59	0.13	<.0001	0.64	0.03	<.0001	32.43	1.19	<.0001	4.84	0.20	<.0001

AVLT = Auditory Verbal Learning Test (Long Term Memory score); MMSE = Mini Mental Status Examination; COWAT = Controlled Oral Word Association Test; JLO = Judgement of Line Orientation; SE = Standard Error