. Author manuscript; available in PMC: 2010 Aug 27.

Published in final edited form as: N Engl J Med. 2009 Jul 16;361(3):255–263. doi: 10.1056/NEJMoa0809437

Table 4a.

Observed and Fitted Mean Auditory Verbal Learning Test Long Term Memory Score at First Examination and Annual Change by Age Deciles: APOE e4 Carriers and Noncarriers

	AVLT-LTM at First Examination								Annual Change in AVLT-LTM
	Noncarriers				Carriers				Noncarriers				Carriers
	Observed⁽¹⁾			Model⁽²⁾	Observed⁽¹⁾			Model⁽²⁾	Observed⁽³⁾			Model⁽⁴⁾	Observed⁽³⁾			Model⁽⁴⁾
Age Decile	N	Mean	SD	Model⁽²⁾	N	Mean	SD	Model⁽²⁾	N	Mean	SD	Model⁽⁴⁾	N	Mean	SD	Model⁽⁴⁾
20-29	9	12.44	2.07	12.26	6	11.00	2.97	11.03	1	0.25	.	0.14	2	0.50	0.71	0.40
30-39	22	10.64	2.63	10.27	24	10.13	2.85	10.24	12	−0.50	1.06	0.12	12	0.31	0.53	0.29
40-49	27	10.48	2.42	10.44	36	10.00	3.57	9.83	18	0.12	0.82	0.09	16	0.14	1.15	0.18
50-59	169	9.63	3.10	9.50	114	9.92	3.10	9.55	92	0.10	0.81	0.07	76	−0.03	0.96	0.08
60-69	148	8.89	2.91	8.84	78	8.10	3.51	8.21	134	−0.05	1.18	0.04	88	0.02	1.18	−0.03
70-79	83	8.70	3.53	8.73	40	8.18	2.77	7.94	78	0.12	0.99	0.02	39	−0.61	1.65	−0.13
80-89	29	9.38	2.97	8.81	14	6.43	3.52	6.48	39	−0.33	1.66	−0.01	14	−0.46	1.49	−0.24
90-99	4	10.50	4.43	9.18	1	11.00	.	10.36	8	0.21	1.39	−0.03	1	0.48	.	−0.35

AVLT = Auditory Verbal Learning Test (Long Term Memory score).

⁽¹⁾

Observed AVLT score at first examination per subject summarized for each age decile.

⁽²⁾

Predicted (empirical best linear unbiased predictor) AVLT score at first examination per subject based on the AVLT mixed model (Table 2) averaged for each age decile.

⁽³⁾

Slope of simple linear regression line computed per subject (using all observations for that subject within the age decile) summarized for each age decile.

⁽⁴⁾

Predicted annual change in AVLT at the beginning of the age decile based on the AVLT mixed model (Table 2).