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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Nat Rev Urol. 2010 May;7(5):277–285. doi: 10.1038/nrurol.2010.47

Figure 5. The FLCN pathway.

Figure 5

A. FLCN is the gene for the Birt-Hogg-Dubé (BHD) syndrome. Patients affected with BHD are characterized by germline mutation of the FLCN gene. The FLCN/FNIP1/FNIP2 complex binds AMPK and FLCN is phosphorylated by a rapamycin-sensitive kinase (i.e.,mTORC1). B. When FLCN is deficient, AKT, mTORC1 and mTORC2 are activated. From Hasumi, et al.(8)