Figure 6. IBMPFD patient myoblasts show accumulation of large LAMP-positive vesicles and LC3-II protein.
(A) Immunostaining for VCP and LAMP-1 in myoblasts derived from normal control or an IBMPFD patient. Cells were observed with a 63× objective. Please see Suppl. Fig. 6 for cell lines from additional patients and additional markers. (B) Western blot analysis of LC3 in myoblast lysates from 2 control samples and samples from 2 IBMPFD patients.