Table 2.
Estimated time of the most recent common ancestor (TMRCA) and other evolutionary parameters estimated for lineages or groups of viruses in the dataset used in this study
| Lineage or group | TMRCA (95% HPDs*) | Mean evolutionary rate in s/s/y† (95% HPDs) | dN/dS‡ |
|---|---|---|---|
| American Subtype III | 1991 (1989–1992) | 7.4 (5.4–9.1) × 10−4 | 0.044 |
| Venezuelan | 1999 (1997–2000) | 4.7 (1.4–7.9) × 10−4 | 0.053 |
| Ecuadorian | 1997 (1996–1999) | 8.6 (5.7–11.5) × 10−4 | 0.052 |
| Brazilian | 1997 (1996–1998) | 7.2 (2.1–11.8) × 10−4 | 0.099 |
| Medellín viruses | 1991 (1989–1993) | 3.6 (1.7–7.7) × 10−4 | 0.033 |
*
95% HPDs: 95% highest probability density.
†
s/s/y: substitutions per site per year.
‡
dN/dS: average ratio of nonsynonymous substitutions per nonsynonymous site to synonymous substitutions per synonymous site.