IL-1α promoter activity is enhanced and IL-1α protein expression is increased following suppression of Osx. A. The IL-1α promoter reporter construct was transfected into different cells as indicated. Luciferase activity was measured 24 h later. Relative fold activity was calculated as the normalized luciferase value divided by the normalized luciferase value in Dunn or DLM8 cells. B. IL-1α protein in Dunn, Dunn-si-c, Dunn-si-2, DLM8, DLM8-si-c, and DLM8-si-1 cell lysate was quantified by ELISA. Relative fold was calculated as the normalized protein concentration divided by the normalized protein concentration in Dunn or DLM8 cells.