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. Author manuscript; available in PMC: 2010 Aug 27.
Published in final edited form as: Biochemistry. 2009 Jun 16;48(23):5187–5198. doi: 10.1021/bi802067u

Figure 1.

Figure 1

Initial lead organometallic inhibitor identification for BRAF kinase. (a) Chemical structures of staurosporine and the organoruthenium scaffold library. (b) Initial screen of the organometallic compound library using the ELISA-based BRAF activity. Relative light units (RLU) are plotted for duplicate measurements along the abscissa and ordinate, and inhibitors that yield the lowest RLU values along the diagonal represent the most potent and reproducible inhibitors. (c) Chemical structure of the racemic BRAF lead inhibitor HB591 identified from the organometallic compound library.