Table 1.
Crystallographic Data Collection and Structural Refinement Statistics
| data collection | APS 23ID-B with 10 μm minibeam |
| complex | BRAF–CS292 |
| space group | P41212 |
| cell dimensions | |
| a, c (Å) | 94.91, 163.35 |
| resolution (Å) | 50−3.2 |
| Rmergea,b | 0.277 (0.735) |
| I/σ(I)a | 9.9 (2.2) |
| completenessa (%) | 99.9 (99.0) |
| multiplicitya | 13.3 (6.4) |
| refinement | |
| Rworkc/Rfreed | 23.2%/28.0% |
| root-mean-square deviation | |
| bond lengths (Å) | 0.0099 |
| bond angles (deg) | 1.54 |
a
Data for the highest-resolution shell shown in parentheses.
b
Rmerge = Σhkl|I(hkl)−〈I(hkl)〉|/Σhkl|I(hkl), where 〈I(hkl)〉 is the mean of the sym-metry-equivalent reflections of I(hkl).
c
Rwork = Σ‖Fo| – |Fc‖/|Fo|.
d
Rfree=ΣT‖Fo|–|Fc‖/ΣT|Fo| (where T is a test data set of 9.3% of the total reflections randomly chosen and set aside before refinement).