Table 1.

Interactions of germline Tudor domain-containing proteins with Piwi proteins

Tudor domain- containing proteins	Organism	Number of Tudor domains	Other domains present in Tudor proteinsa	Interacting Piwi protein	References
Tudor	Fruit fly	11	Not found	Aubergine, Ago3	[35,69,80,83]
SpnE	Fruit fly	1	DExH, HA	Not found	[111]
Krimp/Mtc	Fruit fly	1	Not found	Not found	[7,112]
Otu	Fruit fly	1	OTU	Not found	[59,60]
Tejas	Fruit fly	1	Tejas	Aubergine	[64]
Akap1	Mammalsb	1	KH type 1	Not found	[51,56]
Tdrd5	Mammals	1	Tejas	Not found	[51,56,64]
Tdrd8/Stk31	Mammals	1	Ser/Thr PK-like	Miwi	[51,56]
Tdrd9	Mammals	1	DExH, HA	Miwi, Mili, Miwi2	[51,56,68]
Tdrd2/Tdrkh	Mammals	1	KH type 1	Miwi, Mili, Miwi2	[51,56,68]
Tdrd4/Rnf17	Mammals	5	RING	Miwi	[51,56,68]
Tdrd7	Mammals	3	Tejas	Miwi	[51,56,64,68]
Tdrd1	Mammals	4	MYND	Miwi, Mili, Miwi2	[46,51,56,68,80, 81,84]
Tdrd6	Mammals	8	Not found	Miwi, Mili	[51,56,67–69]
Xtr	Frog	7	vWA	Xiwi	[58,80,82]

^aDExH – RNA helicase DExH family; HA – Helicase-associated domain; OTU – Ovarian Tumor-related putative cysteine proteases; Tejas – novel ~140 amino acid domain with unknown function [64]; KH type 1 – K Homology RNA-binding domain type 1; Ser/Thr PK-like – serine/threonine protein kinase-like domain; RING – RING-type zinc finger; MYND – MYND (myeloid, Nervy, DEAF-1)-type zinc finger; vWA – von Willebrand factor type A domain (putative protein-protein interaction module).

^bMammalian germline Tud-domain-containing proteins identified based on preferential expression of their corresponding genes in human male germline cells (spermatocytes) [51,56].